I am a doctor trained at the University of Cambridge and an aspiring cardiac surgeon.
Currently, I am undertaking a seven-year specialty training post in Cardiothoracic Surgery in the East of England. I am also a Teaching By-fellow at Churchill College in the University of Cambridge, teaching undergraduate natural scientists and medical students.
I obtained an undergraduate research degree in Physiology, and my project investigated murine models of arrhythmic syndromes and the effects of metabolic derangement on the formation of myocardial arrhythmic substrate. This work has since been published in peer-reviewed journals. Extra-curricular interests of mine include distance running, astronomy, and aviation/flight simulators.
CV
Education
| University of Cambridge, UK | MA | 2022 |
| MB BChir | 2021 | |
| BA (Hons) | 2018 |
Research
| Publications |
|---|
| For a full list of publications please see this link |
| Original research |
| Saadeh K, Chadda KR, Ahmad S, Valli H, Nanthakumar N, Fazmin IT, Edling CE, Huang CLH, Jeevaratnam K. Molecular basis of ventricular arrhythmogenicity in a Pgc-1α deficient murine model. Molecular Genetics and Metabolism Reports. 2021 April. DOI:10.1016/j.ymgmr.2021.100753 |
| Fazmin IT, Rafiq MU, Nashef SA, Ali JM. Inferior outcomes following cardiac surgery in patients with a functioning renal allograft. Interactive CardioVascular and Thoracic Surgery. 2020 September. PMID:33212501. DOI:10.1093/icvts/ivaa245 |
| Saadeh K, Achercouk Z, Fazmin IT, Nantha Kumar N, Salvage SC, Edling CE, Huang CLH, Jeevaratnam K. Protein expression profiles in murine ventricles modeling catecholaminergic polymorphic ventricular tachycardia: effects of genotype and sex. Annals of the New York Academy of Sciences. 2020 Jul 26. PMID 32713021 DOI:10.1111/nyas.14426 |
| Edling CE, Fazmin IT, Saadeh K, Chadda KR, Ahmad S, Valli H, Huang CL, Jeevaratnam K. Molecular basis of arrhythmic substrate in ageing murine peroxisome proliferator-activated receptor gamma coactivator deficient (Pgc-1β-/-) hearts modelling mitochondrial dysfunction. Bioscience reports. 2019 Nov. PMID:31778152. DOI:10.1042/BSR20190403 |
| Edling CE, Fazmin IT, Chadda K, Ahmad S, Valli H, Huang C, Jeevaratnam K. Atrial transcriptional profiles of molecular targets mediating electrophysiological function in ageing and Pgc-1β deficient murine hearts. Frontiers in Physiology. 2019;10:497. PMID:31068841. DOI:10.3389/fphys.2019.00497. |
| Edling CE, Fazmin IT, Chadda KR, Ahmad S, Valli H, Grace AA, Huang CL, Jeevaratnam K. Ageing in Pgc-1β-/-mice modelling mitochondrial dysfunction induces differential expression of a range of genes regulating ventricular electrophysiology. Bioscience Reports. 2019 Mar 26:BSR20190127. PMID:30914453. DOI:10.1042/BSR20190127. |
| Review articles |
| Fazmin IT, Ali JM. Prosthesis-Patient Mismatch and Aortic Root Enlargement: Indications, Techniques and Outcomes. J Cardiovasc Dev Dis. 2023 Sep 1;10(9):373. DOI:10.3390/jcdd10090373. PMID: 37754802 |
| Saadeh K, Nantha Kumar N, Fazmin IT, Edling CE, Jeevaratnam K. Anti-malarial drugs: mechanisms underlying their proarrhythmic effects. British Journal of Pharmacology. 2022 Sep 27. DOI:10.1111/bph.15959. PMID: 36165125. |
| Nantha Kumar N, Nyatsuro K, Ahmad S, Fazmin IT, Saadeh K, Tse G, Jeevaratnam K. Systematic review of renal denervation for the management of cardiac arrhythmias. Clin Res Cardiol. 2021 Nov 8. DOI:10.1007/s00392-021-01950-8. PMID: 34748053. |
| Saadeh K, Fazmin IT. Mitochondrial dysfunction increases arrhythmic triggers and substrates; potential anti-arrhythmic pharmacological targets. Frontiers In Cardiovascular Medicine. 2021. DOI:10.3389/fcvm.2021.646932. |
| Abu-Omar Y, Fazmin IT, Ali JM, Pelletier MP. Minimally invasive mitral valve surgery. Journal of Thoracic Disease. 2020. PMID:33841982. DOI:10.21037/jtd-20-2114 |
| Fazmin IT, Achercouk Z, Edling CE, Said A, Jeevaratnam K. Circulating microRNA as a Biomarker for Coronary Artery Disease. Biomolecules. 2020 Sep 23. PMID:32977454. DOI:10.3390/biom10101354. |
| Fazmin IT, Huang CL, Jeevaratnam K. Bisphosphonates and atrial fibrillation: revisiting the controversy. Annals of the New York Academy of Sciences. 2020 Mar 24. PMID:32208537 DOI:10.1111/nyas.14332 |
| Chadda KR, Fazmin IT, Ahmad S, Valli H, Edling CE, Huang CL, Jeevaratnam K. Arrhythmogenic mechanisms of obstructive sleep apnea in heart failure patients. Sleep. 2018 Jul 16;41(9):zsy136. PMID:30016501. DOI:10.1093/sleep/zsy136. |
| Case reports |
| Fazmin IT, Zhang R, Martin CA. Pleuritic chest pain post catheter ablation procedure. BMJ Heart. 2021. DOI:10.1136/heartjnl-2021-319721. PMID:34521735 |
| Letters |
| Fazmin IT, Ali JM. Re-exploration and bleeding rates after cardiac surgery can be reduced-The utility of a checklist. J Card Surg. 2020. PMID:33135219 DOI:10.1111/jocs.15142 |
| Presentations |
|---|
| Oral presentations |
| Fazmin IT, Rafiq MU, Nashef SA, Ali JM. Inferior survival following cardiac surgery in patients with a functioning renal allograft. Cambridge National Cardiology Conference 2020, organised by the Cambridge University Cardiology Society, February 2020, Cambridge, UK |
| Poster presentations |
| Fazmin IT, Edling CE, Saadeh K, Chadda KR, Valli H, Ahmad S, Huang CLH, Jeevaratnam K. Transcriptional and protein expression changes associated with pro-arrhythmic phenotypes in ageing and Pgc-1β knockout murine models of mitochondrial dysfunction. 4th EU-CardioRNA Working Group Meeting, February 2020, Maastricht, The Netherlands |
| Fazmin IT, Zhang RY, Porto A, Divulwewa K, Reddy A, Gonzalez-Panizo J, di Nubila B, Mausa MF, Agarwal S, Begley D, Flynn S, Grace A, Heck P, Mellor G, Virdee M, Martin CA. Improved outcome in ablation of ventricular tachycardia in patients with structural heart disease under general anaesthetic. Heart Rhythm Congress 2019, organised by the British Heart Rhythm Society and Arrhythmia Alliance, October 2019, Birmingham, UK |
| Fazmin IT, Edling CE, Chadda KR, Ahmad S, Valli H, Huang CLH, Jeevaratnam K. Molecular basis of arrhythmic substrate in ageing, Pgc-1β-deficient, murine hearts modelling mitochondrial dysfunction. Europhysiology 2018, organised by the Physiological Society, September 2018, London, UK Winner, Rob Clarke Silver Award for Undergraduate Research |
Teaching experience
| Churchill College, University of Cambridge | 2018-Present |
|---|---|
| Teaching By-Fellow | |
| Formal teaching appointment for small group teaching for first-year medical students and second-year natural scientists on course content and exam preparation. Underwent centrally organised training by the University of Cambridge Centre for Teaching and Learning and am accredited for teaching life sciences at the undergraduate level. Acted up as Director of Studies in Pre-Clinical Medicine for the 2022-23 academic year. https://www.chu.cam.ac.uk/fellows/dr-talal-fazmin/ |
| School of Clinical Medicine, University of Cambridge | 2019-2020 |
|---|---|
| Associate clinical supervisor Formal teaching appointment, teaching fourth year Student Doctors clinical examination skills. |
2019-2020 |
| Intermediate Clinical Supervisor Ward based teaching aimed at third year pre-clinical medical students to get them comfortable interacting with patients in a clinical setting. |
2019-2020 |
| Preparing for Patients B Facilitator Formal teaching appointment, ward based teaching for second year pre-clinical medical students, teaching them communication skills. This was followed by leading a debrief session to reflect on lessons learnt and areas to improve upon. |
2019-2020 |
Prizes and awards
| 2022 | Terumo Aortic Best Presentation Award Royal Papworth Aortic Symposium |
| 2020 | Student Led Teaching Award - Shortlisted, Innovative Teaching Award University of Cambridge |
| 2018 | Rob Clark Silver Award for Undergraduate Research The Physiological Society, UK |
| 2017 | Biomedical Vacation Scholarship Wellcome Trust |
| 2017 | Prize Scholarship Churchill College, University of Cambridge |
| 2017 | Medical and veterinary prize Churchill College, University of Cambridge |